Key result
Correction of chronic hypoxemia with oxygen significantly improved reflex vasoconstriction during lower body negative pressure (p<0.02), preventing the hypotension observed while patients breathed room air.
Why the study?
Does correction of hypoxemia improve reflex vasoconstriction in chronically hypoxemic patients?
Population
8 ambulatory patients with chronic hypoxemia and a variety of chronic pulmonary diseases. Inclusion…
Comparison
Correction of hypoxemia by breathing 40-100%… vs Breathing room air.
Design
Other, The order of the gases was alternated for the eight patients.
Follow-up
Acute physiological observation (minutes)
Authors
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Oxygen may restore reflex vasoconstriction in chronic hypoxemia; leaves open confirmation in randomized trials before practice change.
Does correction of hypoxemia improve reflex vasoconstriction in chronically hypoxemic patients?
p-value: p=<0.02
Correction of chronic hypoxemia with oxygen restores impaired reflex vasoconstriction and prevents hypotension during pooling of blood, highlighting the therapeutic importance of oxygen in hypotensive hypoxemic patients.
Heistad et al. (1972) studied Chronic hypoxemia (n=8). Oxygen therapy vs. Room air was evaluated on Change in forearm vascular resistance during lower body negative pressure (p=<0.02). Correction of chronic hypoxemia with oxygen significantly improved reflex vasoconstriction during lower body negative pressure (p<0.02), preventing the hypotension observed while patients breathed room air.
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