Key result
Onychomadesis developed exclusively on nails that had prior cutaneous lesions from severe hand-foot-mouth disease, suggesting direct inflammation as a potential mechanism.
Case Report (n=1)
Suggests that nail dysfunction due to direct inflammation from skin eruptions around the nail is a cause of onychomadesis linked to HFMD.
May link onychomadesis to local HFMD inflammation; hypothesis-generating case report requiring prospective confirmation before clinical adoption.
This paper reported a case of onychomadesis which appeared on the nails after heal of cutaneous lesions of hand-foot-mouth disease (HFMD). There were a few reports describing onychomadesis after HFMD; however, the mechanism is still unclear. The present case was prospectively observed, and onychomadesis was found to develop only on the nails having cutaneous lesions of HFMD. We considered that nail dysfunction due to direct inflammation spreading from skin eruptions around nail is one of the causes of onychomadesis linked to HFMD.
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Shikuma et al. (2011) conducted a case report in Hand-foot-mouth disease (HFMD) and onychomadesis (n=1). Cutaneous lesions of HFMD around nails was evaluated on Development of onychomadesis. Onychomadesis developed exclusively on nails that had prior cutaneous lesions from severe hand-foot-mouth disease, suggesting direct inflammation as a potential mechanism.
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