Key result
Bronchial-hypersensitive guinea pigs exhibited higher high-frequency power and a lower LF/HF ratio throughout the day compared to bronchial-hyposensitive guinea pigs, indicating predominant parasympathetic activity.
Bronchial-hypersensitive guinea pigs demonstrate predominant parasympathetic nervous activity and distinct diurnal autonomic rhythms compared to hyposensitive strains, suggesting their utility as models for asthma chronobiology.
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Hypothesis-generating for autonomic mechanisms in asthma models; requires human validation before clinical relevance.
We studied the characteristics of the rhythmicity of heart rate (HR), body temperature (BT), locomotor activity (LA) and autonomic nervous activity in bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs. For this purpose, HR, BT, LA, and electrocardiogram (ECG) were recorded from conscious and unrestrained guinea pigs using a telemetry system. Autonomic nervous activity was analyzed by power spectral analysis of heart rate variability. Nocturnal patterns, in which the values in the dark phase (20:00-06:00) were higher than those in the light phase (06:00-20:00), were observed in HR, BT and LA in both strains of guinea pigs. The autonomic nervous activity in BHS guinea pigs showed a daily pattern, although BHR guinea pigs did not show such a rhythmicity. The high frequency (HF) power in BHS guinea pigs was higher than that in BHR guinea pigs throughout the day. Moreover, the low frequency/high frequency (LF/HF) ratio in BHS guinea pigs was lower than that in BHR guinea pigs throughout the day. These results suggest that parasympathetic nervous activity may be predominant in BHS guinea pigs.
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AKITA et al. (2004) studied Bronchial hypersensitivity (asthma model) (n=14). Bronchial-hypersensitive (BHS) strain vs. Bronchial-hyposensitive (BHR) strain was evaluated on High frequency (HF) power and LF/HF ratio of heart rate variability. Bronchial-hypersensitive guinea pigs exhibited higher high-frequency power and a lower LF/HF ratio throughout the day compared to bronchial-hyposensitive guinea pigs, indicating predominant parasympathetic activity.
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