The chromosomes were studied in direct preparations of 10 primary carcinomas, induced in rats by the application of 7,12-dimethylbenz(a)anthracene (DMBA) to the auricular skin. The chromosome variation accompanying the malignant growth was definitely non-random and involved preferentially 2 chromosome types, A2 and members of the D group. This chromosome pattern was of the same type as reported earlier in DMBA-induced leukemias and sarcomas of the rat. The present results support the conclusion that the inducing factor—not the tissue origin of the tumour—determines the karyotypic evolution.
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Ulf Ahlström (2009) studied this question.