Key result
Numerous potent and subtype-selective P2X receptor antagonists have been developed and are currently being investigated for therapeutic usefulness in a variety of disorders.
This review summarizes the pharmacology of P2X receptors and highlights the development of subtype-selective antagonists with potential therapeutic applications in various diseases.
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P2X antagonists may expand options for pain and inflammation; leaves open clinical efficacy pending randomized trials.
Syed et al. (2011) conducted a review in Thrombosis, pain, dysfunctional urinary bladder, arthritis, and depression. P2X receptor antagonists was evaluated. Numerous potent and subtype-selective P2X receptor antagonists have been developed and are currently being investigated for therapeutic usefulness in a variety of disorders.
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