Key result
Electrical stimulation of the carotid sinus nerves demonstrated parallel baroreflex effects on the sinoatrial node and the AV node, prolonging the AV interval via the AH interval.
Why the study?
Does electrical stimulation of the carotid sinus nerves prolong atrioventricular conduction time in patients with coronary artery disease?
Case Report (n=2)
Does electrical stimulation of the carotid sinus nerves prolong atrioventricular conduction time in patients with coronary artery disease?
This study provides the first demonstration in humans of parallel baroreflex effects on the sinoatrial and AV nodes via carotid sinus nerve stimulation.
May indicate baroreflex AV nodal effects; leaves open clinical role of carotid sinus stimulation in CAD.
Electrical stimulation of the carotid sinus nerves was applied during diagnostic catheterization of two patients who had coronary artery disease. The immediate reflex prolongation of the atrioventricular (AV) interval was due to prolongation of the AH interval only and was roughly parallel to the reflex RR interval prolongation evoked without atrial pacing. After cholinergic block, the reduced prolongation of both the RR interval and the AV interval caused by reflex inhibition of sympathetic tone followed a time course similar to the arterial pressure decrease. This is the first demonstration in man of the parallel baroreflex effects on the sinoatrial node and the AV node.
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Borst et al. (1982) conducted a case report in Coronary artery disease (n=2). Electrical stimulation of the carotid sinus nerves was evaluated on Atrioventricular (AV) interval prolongation. Electrical stimulation of the carotid sinus nerves demonstrated parallel baroreflex effects on the sinoatrial node and the AV node, prolonging the AV interval via the AH interval.
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