Key result
Stimulation of the carotid sinus baroreceptors produced a reflex negative inotropic effect directly upon the atrial and ventricular myocardium, mediated by the sympathetic nervous system.
Why the study?
Does stimulation of the carotid sinus baroreceptors affect myocardial contractility in an isolated left heart preparation?
Population
Auxotonic and isovolumetric left heart preparations (innervated, hydraulically isolated)
Design
Preclinical
Authors
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May inform baroreflex device strategies in HF; leaves open direct myocardial translation in humans.
Does stimulation of the carotid sinus baroreceptors affect myocardial contractility in an isolated left heart preparation?
Stimulation of carotid sinus baroreceptors exerts a direct reflex negative inotropic effect on the atrial and ventricular myocardium mediated by the sympathetic nervous system.
Geest et al. (1964) studied this question. Stimulation of the carotid sinus baroreceptors was evaluated on Left atrial and ventricular performance. Stimulation of the carotid sinus baroreceptors produced a reflex negative inotropic effect directly upon the atrial and ventricular myocardium, mediated by the sympathetic nervous system.
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