Why the study?
Does raising carotid sinus perfusion pressure reduce myocardial contractility in a canine model?
Population
21 dogs placed on total cardiopulmonary bypass with isolated carotid sinus regions perfused with fully…
Comparison
Raising the pressure distending the carotid… vs Baseline carotid sinus distending pressure of…
Design
Preclinical
Authors
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Hypothesis-generating in canines; extends prior observations by controlling for cerebral ischemia.
Does raising carotid sinus perfusion pressure reduce myocardial contractility in a canine model?
The inverse relationship between carotid sinus perfusion pressure and indices of contractility demonstrates that carotid sinus baroreceptors directly modulate myocardial performance.
Gerald Glick (1971) studied this question.
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