Key result
A ≥10% increase in heart rate is a poor predictor of true coronary hyperemia during intravenous adenosine infusion, occurring in only 37.3% of patients with confirmed hyperemia.
Why the study?
Is heart rate response a reliable surrogate marker of adenosine-induced coronary hyperemia in patients undergoing invasive physiological assessment?
Population
265 patients undergoing invasive FFR measurements with IV adenosine infusion at a single center, mean age…
Design
Cohort
Authors
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Heart rate rise should not confirm hyperemia during adenosine stress testing; this Level 4 analysis leaves open validation of reliable noninvasive surrogates.
Observational (n=265)
No
Is heart rate response a reliable surrogate marker of adenosine-induced coronary hyperemia in patients undergoing invasive physiological assessment?
p-value: p=0.77
Heart rate increase is an unreliable surrogate marker for adenosine-induced coronary hyperemia, suggesting that reliance on a ≥10% heart rate increase during non-invasive stress imaging may misclassify patients as non-responders.
Modi et al. (2018) conducted an observational in Coronary artery disease (n=265). Heart rate response to intravenous adenosine vs. Invasive pressure-wire markers of hyperemia was evaluated on Correlation of heart rate change with true coronary hyperemia (p=0.77). A ≥10% increase in heart rate is a poor predictor of true coronary hyperemia during intravenous adenosine infusion, occurring in only 37.3% of patients with confirmed hyperemia.
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