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July 1, 2015JACC: Cardiovascular InterventionsOpen Access

Repeatability of Fractional Flow Reserve Despite Variations in Systemic and Coronary Hemodynamics

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Why the study?

Does an automated 'smart minimum' algorithm provide reproducible FFR values comparable to human core laboratory analysis during intravenous adenosine infusion?

Population

206 patients from the VERIFY study who were infused with intravenous adenosine at 140 μg/kg/min and measured…

Comparison

Automated 'smart minimum' FFR algorithm during… vs Human core laboratory analysis

Design

Cohort

Authors

NJNils P. JohnsonInterventional CardiologyDJD. T. JohnsonMemorial HermannRKRichard L. KirkeeideMemorial Hermann

Discussion

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Implication

Supports automated FFR during adenosine; leaves open outcome trials before routine adoption.

Structured PICO

Does an automated 'smart minimum' algorithm provide reproducible FFR values comparable to human core laboratory analysis during intravenous adenosine infusion?

P
Population
206 patients (190 complete pairs after exclusions) from the VERIFY study who were infused with intravenous adenosine at 140 μg/kg/min and measured FFR twice
I
Intervention
Automated 'smart minimum' FFR algorithm during intravenous adenosine infusion at 140 μg/kg/min
C
Comparator
Human core laboratory analysis
O
Outcome
Repeatability of FFR and comparison of automated algorithm versus human core laboratory analysissurrogate

An automated 'smart minimum' algorithm for FFR during adenosine infusion is highly reproducible and comparable to human core laboratory analysis, supporting its reliable use in clinical practice.

Cite This Study

Johnson et al. (2015) studied this question.

synapsesocial.com/papers/6a85232e404dce2ee642e9achttps://doi.org/10.1016/j.jcin.2015.01.039

Topics

Coronary artery diseaseCoronary CT angiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multicenter Core Laboratory Comparison of the Instantaneous Wave-Free Ratio and Resting P /P With Fractional Flow Reserve2013 · 348 citations
  2. 2Variations of coronary hemodynamic responses to intravenous adenosine infusion: Implications for fractional flow reserve measurements2013 · 36 citations
  3. 3Simultaneous Coronary Pressure and Flow Velocity Measurements in Humans1996 · 455 citations
  4. 4Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease2012 · 2,786 citations
  5. 5Hemodynamic Response to Intravenous Adenosine and Its Effect on Fractional Flow Reserve Assessment2013 · 62 citations