What question did this study set out to answer?

To evaluate arterial plasma metabolite alterations during compensatory milk secretion and assess whether circulating essential amino acid concentrations act as rate-limiting factors in lactation.

April 7, 1983Quarterly Journal of Experimental Physiology

Arterial Plasma Composition During Compensatory Increase in Milk Secretion in the Goat: Relation to Rate Limitation

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Authors

AHAlan J. HendersonScottish Environment Protection Agency MPM. PeakerNHS Ayrshire and Arran

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Implication

Experimental study reveals altered arterial plasma metabolites during compensatory milk secretion in goats, indicating circulating essential amino acids do not limit lactation rate.

Key Points

To evaluate arterial plasma metabolite alterations during compensatory milk secretion and assess whether circulating essential amino acid concentrations act as rate-limiting factors in lactation.
Injected colchicine into a single mammary gland of goats at peak lactation to selectively suppress local milk production.
Measured subsequent milk secretion rates in both the treated gland and the contralateral untreated gland.
Monitored changes in arterial plasma concentrations of glucose, acetate, and individual amino acids.
Milk secretion in the colchicine-treated gland fell to 40% of baseline, while secretion in the untreated gland concurrently rose to 126% of baseline.
Arterial plasma concentrations of glucose and tyrosine increased, while concentrations of lysine, arginine, asparagine, glycine, alanine, and ornithine decreased significantly.
Arterial concentrations of acetate and other amino acids showed no significant changes, contradicting the hypothesis that circulating essential amino acids determine the maximal rate of milk secretion.

Cite This Study

Henderson et al. (1983) studied this question.

synapsesocial.com/papers/6a939aa7a05f7032207c00a1 https://doi.org/10.1113/expphysiol.1983.sp002712

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Implication

Experimental study reveals altered arterial plasma metabolites during compensatory milk secretion in goats, indicating circulating essential amino acids do not limit lactation rate.

Arterial Plasma Composition During Compensatory Increase in Milk Secretion in the Goat: Relation to Rate Limitation

Discussion

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Implication

Key Points

Cite This Study

Arterial Plasma Composition During Compensatory Increase in Milk Secretion in the Goat: Relation to Rate Limitation

Discussion

Member takes

Implication

Key Points

Cite This Study

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