Key result
An instrument combining time-resolved spectrofluorometry and diffuse reflectance spectroscopy achieved 100% diagnostic accuracy in infarcted areas and 94.44% in border zones in a rat model of heart failure.
Why the study?
Does time-resolved spectrofluorometry and diffuse reflectance spectroscopy accurately detect structural and metabolic changes in a rat model of post-MI heart failure?
Does time-resolved spectrofluorometry and diffuse reflectance spectroscopy accurately detect structural and metabolic changes in a rat model of post-MI heart failure?
Time-resolved autofluorescence and diffuse reflectance spectroscopy can accurately identify structural and metabolic changes in failing myocardium in vivo without exogenous labels.
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Supports label-free optical mapping in rat post-MI HF; leaves open human validation and clinical translation.
Lagarto et al. (2015) studied Myocardial infarction and heart failure (n=12). Time-resolved spectrofluorometry and diffuse reflectance spectroscopy vs. Age-matched controls was evaluated on Diagnostic accuracy to predict tissue disease state. An instrument combining time-resolved spectrofluorometry and diffuse reflectance spectroscopy achieved 100% diagnostic accuracy in infarcted areas and 94.44% in border zones in a rat model of heart failure.
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