Key result
Spontaneous inspiration significantly decreased the ratio of early to late peak filling velocity by 16% (P<0.01) and increased late peak filling velocity by 10% (P<0.05) in healthy children.
Why the study?
Does spontaneous respiration affect left ventricular diastolic filling patterns in healthy children?
Observational (n=20)
Does spontaneous respiration affect left ventricular diastolic filling patterns in healthy children?
Assessment of left ventricular diastolic function in children using Doppler echocardiography should be standardized with regard to respiratory phases due to significant respiratory variations.
Answers are grounded in this paper and cite their sources.
Respiratory phase may influence pediatric diastolic Doppler indices; leaves open whether standardization improves diagnostic accuracy.
Pulsed Doppler echocardiographic indices of mitral valve filling were measured in 20 healthy children, between 3 and 12.5 years old, in order to evaluate the effects of spontaneous respiration on left ventricular diastolic filling patterns. There were significant respiratory variations in four parameters of left ventricular diastolic function: The peak early filling velocity, the ratio of early to late peak filling velocity, and the ratio of early to late diastolic velocity-time integral decreased significantly during inspiration (mean decrease 7%, P < 0.05; 16%, P < 0.01; and 12%, P < 0.05, respectively). On the other hand there was a significant increase in late peak filling velocity with inspiration (10% increase, P < 0.05). Other variables of left ventricular diastolic filling were unchanged with inspiration. These results suggest that assessment of left ventricular diastolic function in children should be standardized with regard to respiratory phases in any clinical application.
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Alehan et al. (1996) conducted an observational in Healthy (n=20). Spontaneous respiration (inspiration) vs. Other respiratory phases was evaluated on Ratio of early to late peak filling velocity (16% mean decrease, p=<0.01). Spontaneous inspiration significantly decreased the ratio of early to late peak filling velocity by 16% (P<0.01) and increased late peak filling velocity by 10% (P<0.05) in healthy children.
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