Key result
Daily treatment with inhaled steroids and beta-2 agonists significantly improved right ventricular diastolic filling parameters, including acceleration and deceleration times (P<0.01).
Why the study?
Does treatment with inhaled steroid and beta-2 agonist improve right ventricular diastolic filling parameters in children with moderate asthma?
Observational (n=20)
Does treatment with inhaled steroid and beta-2 agonist improve right ventricular diastolic filling parameters in children with moderate asthma?
p-value: p=<0.01 for acceleration and deceleration time, <0.05 for isovolumetric relaxation time
Treatment of moderate asthma with inhaled steroids and beta-2 agonists improves right ventricular diastolic function in children.
May support RV diastolic benefits from inhaled asthma therapy in children; hypothesis-generating and requires RCTs before practice change.
BACKGROUND: Right ventricular diastolic function has been evaluated in various diseases by the pulsed Doppler technique. Right ventricular diastolic filling parameters show changes with age, heart rate and respiration. Evidences of diastolic left and right ventricular dysfunctions have been reported by echocardiographic studies in asthmatic patients. In the present study, before and after treatment of asthma the right ventricular diastolic filling parameters were compared in children with moderate asthma by Doppler echocardiography (a non-invasive technique). METHODS: The study group consisted of 20 children (eight girls, 12 boys) with asthma. During the present study these patients were treated with inhaled steroid and beta-2 agonist daily. Before treatment all patients were evaluated by Doppler echocardiography. At 4-6 weeks after treatment 15 patients that had shown improvement in their symptoms according to the symptom score were also evaluated by Doppler echocardiography. RESULTS: The mean age was 8.6 +/- 2.69 years and mean period of symptoms were 56.4 +/- 35.8 months. When compared with results of echocardiography before and after treatment, the right ventricular diastolic filling parameters (acceleration time: P < 0.01, deceleration time: P < 0.01 and isovolumetric relaxation time: P < 0.05) were found to be significantly different. CONCLUSIONS: We observed significant improvement of right ventricular diastolic filling parameters by Doppler echocardiography after treatment in children with asthma.
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Uyan et al. (2003) conducted an observational in moderate asthma (n=20). Inhaled steroid and beta-2 agonist vs. Before treatment (baseline) was evaluated on Right ventricular diastolic filling parameters (acceleration time, deceleration time, and isovolumetric relaxation time) (p=<0.01 for acceleration and deceleration time, <0.05 for isovolumetric relaxation time). Daily treatment with inhaled steroids and beta-2 agonists significantly improved right ventricular diastolic filling parameters, including acceleration and deceleration times (P<0.01).
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