Key result
Monoclonal antibodies reacting with HeLa cell surface antigens prevented cytopathic effects caused by coxsackievirus B1 and reduced absorption of coxsackieviruses B1, B5, and B6.
Monoclonal antibodies against HeLa cell surface antigens can prevent the attachment and cytopathic effects of group B coxsackieviruses.
May support receptor-targeted antiviral strategies; leaves open translation from this animal study to clinical use.
Hybridoma cell lines that secrete monoclonal antibodies which react with HeLa cell surface antigens were produced. The monoclonal antibodies prevented cytopathic effects caused by coxsackievirus B1 and significantly reduced the amounts of coxsackieviruses B1, B5, and B6 that absorb to HeLa cells. These antibodies did not protect the cells from poliovirus cytopathic effects, and they had no effect on the attachment of other picornaviruses to HeLa cells.
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Campbell et al. (1983) studied Coxsackievirus infection (in vitro). Monoclonal antibodies reacting with HeLa cell surface antigens was evaluated on Cytopathic effects and viral absorption to HeLa cells. Monoclonal antibodies reacting with HeLa cell surface antigens prevented cytopathic effects caused by coxsackievirus B1 and reduced absorption of coxsackieviruses B1, B5, and B6.
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