Key result
Combined surgical and antibiotic treatment for prosthetic valve endocarditis was associated with a 10-year survival of 58%, compared to 28% with antibiotics alone (p=0.04).
Why the study?
Does treatment with antibiotics alone compared to antibiotics and surgery improve survival in patients with prosthetic valve endocarditis?
Population
66 patients with proven prosthetic valve endocarditis treated in one institution between 1989 and 1999, mean…
Comparison
Antibiotics alone (n=28) vs Combination of antibiotics and surgery (n=38)
Design
Cohort
Follow-up
up to 10 years
Authors
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Surgery with antibiotics may be considered for selected prosthetic valve endocarditis cases; leaves open confirmation of survival benefit in randomized trials.
Cohort (n=66)
No
Does treatment with antibiotics alone compared to antibiotics and surgery improve survival in patients with prosthetic valve endocarditis?
Absolute Event Rate: 58% vs 28%
p-value: p=0.04
While prosthetic valve endocarditis carries high mortality, selected patients can be treated with antibiotics alone, though surgery is associated with better 10-year survival.
Joseph M. Smith (2003) conducted a cohort in Prosthetic valve endocarditis (n=66). Combination of antibiotics and surgery vs. Antibiotics alone was evaluated on Kaplan-Meier survival at 10 years (p=0.04). Combined surgical and antibiotic treatment for prosthetic valve endocarditis was associated with a 10-year survival of 58%, compared to 28% with antibiotics alone (p=0.04).
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