Toxicity of Dicumarol: Review of the Literature and Report of Two Cases

Case Reports1 January 1950TOXICITY OF DICUMAROL: REVIEW OF THE LITERATURE AND REPORT OF TWO CASESJOHN S. POWERS JR.JOHN S. POWERS JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSince the introduction of Dicumarol in 1941 its usefulness as an anticoagulant has been critically studied by many clinicians and investigators.1-15 Initially its use was restricted to the treatment of periperal thromboembolic disease. However, the American Heart Association has carried out an extensive investigation of its efficacy in the prevention of complications of myocardial infarction.Wright and Foley1reviewed the use of anticoagulants in heart disease and gave preliminary observations concerning the large study now in progress. They stated, "Results appear to demonstrate conclusively that this form of therapy is the most satisfactory used to date." Parker and Barker2...Bibliography1. WrightFoley ISWT: Use of anticoagulants in the treatment of disease, Am. J. Med. 3: 718, 1947. CrossrefMedlineGoogle Scholar2. ParkerBarker RLNW: The use of anticoagulants in the management of acute myocardial infarction: a preliminary report, Proc. Staff Meet., Mayo Clin. 22: 185-192, 1947. MedlineGoogle Scholar3. Falk OP: Treatment of coronary artery disease, Dicumarol therapy, J. A. M. A. 134: 491-496, 1947. CrossrefMedlineGoogle Scholar4. AllenHinesKvaleBarker EVEAWFNW: The use of Dicumarol as an anticoagulant: experience in 2,307 cases, Ann. Int. Med. 27: 371, 1947. LinkGoogle Scholar5. EvansDee JAJF: Anticoagulant treatment of postoperative venous thrombosis and pulmonary embolism, New England J. Med. 238: 1, 1948. CrossrefGoogle Scholar6. BarkerHinesKvaleAllen NWEAWFEV: Dicumarol; its action, clinical use and effectiveness as an anticoagulant drug, Am. J. Med. 3: 634, 1947. CrossrefMedlineGoogle Scholar7. ShlevinLederer ELM: Uncontrollable hemorrhage after Dicumarol therapy with autopsy findings, Ann. Int. Med. 21: 332, 1944. LinkGoogle Scholar8. Bauerlin TC: Failure of vitamin K as an antidote in Dicumarol poisoning, Rocky Mountain Med. J. 42: 950, 1945. MedlineGoogle Scholar9. Thorsen G: Dicumarol poisoning with relapse, Lancet 420, 1947. CrossrefMedlineGoogle Scholar10. Cahan A: Hemorrhage and purpura caused by Dicumarin, New England J. Med. 228: 820, 1943. CrossrefGoogle Scholar11. NelsonWashington CMTB: Gross hematuria following the use of Dicumarol, J. Urol. 57: 396-399, 1947. CrossrefMedlineGoogle Scholar12. Zucker HD: Clinical experiences with Dicumarol. Report of 18 cases, J. A. M. A. 124: 217-220, 1944. CrossrefGoogle Scholar13. Allen EV: The emergency treatment of vascular occlusion, J. A. M. A. 135: 15, 1947. CrossrefMedlineGoogle Scholar14. Draper AJ: Dicumarol poisoning, J. A. M. A. 136: 171, 1948. CrossrefMedlineGoogle Scholar15. GefterKramerReinhold WIDWJG: Clinical experiences with Dicumarol, Am. Heart J. 28: 321, 1944. CrossrefGoogle Scholar16. Merrill AJ: Edema and decreased renal blood flow in patients with chronic congestive failure: evidence of forward failure as the primary cause of edema, J. Clin. Investigation 25: 389, 1946. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kingsport, Tennessee*Received for publication October 9, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPseudo-Tumors of the Kidney Secondary to Anticoagulant TherapyExperimental and Clinical Aspects of Drug ToxicityVitamine und VitaminkrankheitenDie thromboembolische Krankheit 1 January 1950Volume 32, Issue 1Page: 146-152KeywordsAnticoagulantsCardiovascular therapyHeartLongitudinal studiesMyocardial infarctionToxicity ePublished: 1 December 2008 Issue Published: 1 January 1950 PDF downloadLoading ...