Key result
Diagnosis of native valve infective endocarditis in 1984-1992 was associated with a non-significant decrease in overall mortality compared to 1975-1983 (12% vs 19%).
Why the study?
Has the clinical spectrum and prognosis of native valve infective endocarditis in non-addicts changed over time?
Population
194 episodes of native valve infective endocarditis in non-addict patients diagnosed from 1975 to 1992
Comparison
Diagnosis and treatment in the later time period vs Diagnosis and treatment in the earlier time period
Design
Cohort
Follow-up
In-hospital
Authors
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Mortality trends in native valve IE appear stable over time; leaves open whether evolving care has altered prognosis in non-addicts.
Cohort (n=194)
Has the clinical spectrum and prognosis of native valve infective endocarditis in non-addicts changed over time?
Absolute Event Rate: 12% vs 19%
p-value: p=non-significant
While the clinical profile of native valve infective endocarditis in non-addicts has shifted toward older patients with less known prior heart disease, overall in-hospital mortality has decreased primarily due to improved surgical outcomes.
Tornos et al. (1995) conducted a cohort in Native valve infective endocarditis in non-addicts (n=194). Diagnosis in recent time period (1984-1992) vs. Diagnosis in earlier time period (1975-1983) was evaluated on Overall mortality (p=non-significant). Diagnosis of native valve infective endocarditis in 1984-1992 was associated with a non-significant decrease in overall mortality compared to 1975-1983 (12% vs 19%).
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