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The syntheses of a number of analogs of a possible intermediate formed in the thymidylate synthetase reaction are described. These consist of a number of 5‐arylaminomethyluracils (X) and N‐methyl‐N‐[1,‐(2′‐deoxy‐β‐D‐ribofuranosyl)thyminyl]‐p‐aminobenzoyl glutamic acid (XXb).
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Daniel V. Santi (1967) studied this question.
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