Key result
Combined IFG and IGT was associated with higher odds of left ventricular hypertrophy compared to normal glucose tolerance (OR 9.76; 95% CI 2.03-46.79; P=0.004).
Why the study?
Is impaired fasting glucose or combined IFG and IGT associated with progressive abnormalities of cardiac geometry and function in nondiabetic, nonhypertensive individuals?
Cross-Sectional (n=562)
Is impaired fasting glucose or combined IFG and IGT associated with progressive abnormalities of cardiac geometry and function in nondiabetic, nonhypertensive individuals?
Odds Ratio: 9.76 (95% CI 2.03–46.79)
p-value: p=0.004
Individuals with combined impaired fasting glucose and impaired glucose tolerance, even without hypertension or diabetes, have a nearly 10-fold higher odds of preclinical cardiovascular disease (LV hypertrophy).
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Combined IFG/IGT may flag higher LVH risk in nondiabetic normotensives; extends cross-sectional observations but leaves causal role open.
Capaldo et al. (2012) conducted a cross-sectional in Abnormal Glucose Regulation (n=562). Combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) vs. Normal glucose tolerance (NGT) was evaluated on Left ventricular (LV) hypertrophy (OR 9.76, 95% CI 2.03-46.79, p=0.004). Combined IFG and IGT was associated with higher odds of left ventricular hypertrophy compared to normal glucose tolerance (OR 9.76; 95% CI 2.03-46.79; P=0.004).
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