Two simple steps, including a new intramolecular [4+3] cycloaddition, are required for the preparation of polycycles that contain a seven-membered ring from 2-methyleneaziridines (see scheme). The diene component is introduced by selective lithiation/alkylation at C3 of the aziridine ring. Lewis acid catalyzed cyclization leads to the products in good yields with stereocontrol.
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Prié et al. (2004) studied this question.
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