An antitumor antibiotic of protein nature1), neocarzinostatin (NCS), was isolated in 1965 from culture filtrates of Streptomyces carzinostaticus var. F-41 by ISHIDA et al.2) It has been reported that NCS inhibits DNA synthesis3) and cell division4), and it causes DNA strand breakage5,6) and induces DNA repair synthe-
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Koide et al. (1980) studied this question.