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Although a relationship between carcinogenesis and stem cell biology has been postulated for a long time, it is only recently that advances in stem cells biology have enabled direct testing of this hypothesis. In traditional or “stochastic” models of carcinogenesis, any cell may become transformed and all cells within a tumor potentially have equally malignant potential. The cancer stem cell hypothesis is a fundamentally different way of describing carcinogenesis. According to this model, cancers arise in cells that display dysregulated self-renewal.
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Max S. Wicha (2009) studied this question.
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