Key result
High-dose methylprednisolone administered during cardiopulmonary bypass did not significantly reduce postoperative infection rates, mechanical ventilation time, or ICU stay in pediatric patients undergoing cardiac surgery.
Why the study?
The study was conducted to evaluate the clinical and laboratory characteristics in pediatric patients undergoing cardiac surgery using steroid during cardiopulmonary bypass.
Do high-dose corticosteroids improve clinical and laboratory outcomes in pediatric patients undergoing cardiac surgery requiring cardiopulmonary bypass?
RCT (n=106)
Randomized
No
Do high-dose corticosteroids improve clinical and laboratory outcomes in pediatric patients undergoing cardiac surgery requiring cardiopulmonary bypass?
Absolute Event Rate: 85.5% vs 96%
p-value: p=>0.05
The use of high-dose corticosteroids during cardiopulmonary bypass in pediatric cardiac surgery does not yield significant clinical benefits.
High-dose corticosteroids should not be used routinely in pediatric cardiac surgery; confirms lack of benefit on infection, fever, and troponin in RCT.
The results of steroid in pediatric after cardiac surgery with steroid during extracorporeal circulation. Objectives: Evaluating the clinical and laboratory characteristics in pediatric patients after cardiac surgery using steroid. Methods: A prospective, randomized, controlled clinical trial on 106 pediatric patients who underwent surgery requiring cardiopulmonary bypass at Hanoi Heart Hospital. Results: The rate of postoperative infection of the group using corticosteroids was 85.5%, the group not using corticosteroids was 96%. The rate of fever after surgery of the group using corticosteroids was 32.7%, the group not using corticosteroids was 35.3%. Troponin T concentration of group using corticosteroids was 1729.3 ± 1874.8 ng/L, group not using corticosteroids was 1855.0 ± 2658.0 ng/L. The time of mechanical ventilation and the time of recovery of the group using corticosteroids was 19.7 ± 23.6 hours and 61.8 ± 53.0 hours, the group not using corticosteroids was 19.8 ± 25.0 hours and 52 ,5 ± 39.1 hours. Conclusion: High-dose corticosteroids in this research did not cause adverse effects as mentioned in some studies, but did not bring any significant benefit to pediatric patients after cardiac surgery.
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Hai et al. (2021) conducted an RCT in Cardiac surgery requiring cardiopulmonary bypass (n=106). Methylprednisolone vs. No corticosteroids was evaluated on Postoperative infection rate (p=>0.05). High-dose methylprednisolone administered during cardiopulmonary bypass did not significantly reduce postoperative infection rates, mechanical ventilation time, or ICU stay in pediatric patients undergoing cardiac surgery.
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