Key result
Extracellular ATP activates a rapid, desensitizing, inward current carried through nonselective cation channels with an apparent unitary conductance of 0.08 pA in guinea pig ventricular myocytes.
Population
Guinea pig ventricular myocytes
Design
Preclinical
Authors
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Does not support clinical changes in arrhythmia or ischemia management; leaves open whether this channel functions in human ventricular myocytes.
Extracellular ATP activates a unique nonselective cation channel in guinea pig ventricular myocytes, distinct from previously cloned ATP-activated channels.
Parker et al. (1995) studied this question. Extracellular ATP was evaluated on Activation of inward current. Extracellular ATP activates a rapid, desensitizing, inward current carried through nonselective cation channels with an apparent unitary conductance of 0.08 pA in guinea pig ventricular myocytes.