Key result
Sympathetic nerve stimulation inhibits gastrointestinal movement through the direct action of released noradrenaline on the smooth muscle, rather than acting on ganglia.
Why the study?
Does sympathetic nerve stimulation inhibit gastrointestinal movement via direct action on smooth muscle or ganglia in animal models?
Population
Rabbit jejunum and guinea-pig stomach models
Comparison
Sympathetic nerve stimulation vs Ganglionic blockade, tetrodotoxin, and vagus…
Design
Preclinical
Authors
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Animal findings clarify noradrenergic GI inhibition mechanism; leaves open human translation and clinical relevance.
Does sympathetic nerve stimulation inhibit gastrointestinal movement via direct action on smooth muscle or ganglia in animal models?
Sympathetic nerve stimulation inhibits gastrointestinal movement through the direct action of released noradrenaline on smooth muscle rather than via ganglia.
Michael D. Gershon (1967) studied Gastrointestinal movement. Sympathetic nerve stimulation vs. Ganglionic blockade, tetrodotoxin, or hexamethonium was evaluated on Mechanism of sympathetic nervous inhibition (site of action). Sympathetic nerve stimulation inhibits gastrointestinal movement through the direct action of released noradrenaline on the smooth muscle, rather than acting on ganglia.
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