Key result
Thermogenic recruitment of brown or brite/beige adipose tissues was not associated with alterations in macrophage complement, suggesting macrophage regulation of thermogenic capacity is unlikely.
Why the study?
A regulatory or mediatory role for macrophages in brown adipose tissue recruitment is debated, with questions regarding whether maintaining this recruited state requires persistent macrophage alterations.
Macrophage regulation of thermogenic capacity in brown and beige adipose tissue is unlikely, as thermogenic recruitment does not alter macrophage complement.
Thermogenic recruitment proceeds independently of macrophages; challenges prevailing hypotheses and leaves open alternative regulators in animal models.
A regulatory or mediatory role-positive or negative-for macrophages in the recruitment of brown adipose tissue is presently discussed. As the recruited state in the tissue is a dynamic process, maintenance of the recruited state would need persistent alterations in macrophage complement. Contrary to this expectation, we demonstrate here an absence of alterations in macrophage complement in thermogenically recruited brown-or brite/beige-adipose tissues. Macrophage regulation of thermogenic capacity is thus less likely.
No takes yet. Share an insight, caveat, or question.
Boulet et al. (2020) studied Thermogenic recruitment of brown and brite/beige adipose tissues. Thermogenic recruitment was evaluated on Macrophage complement alterations. Thermogenic recruitment of brown or brite/beige adipose tissues was not associated with alterations in macrophage complement, suggesting macrophage regulation of thermogenic capacity is unlikely.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: