Key result
Administration of oral norgestrel/ethinyl estradiol led to the cessation of hemorrhage and disappearance of abnormal vasculature in a patient with uterine arteriovenous malformation.
Why the study?
Does oral norgestrel/ethinyl estradiol resolve uterine arteriovenous malformation and associated hemorrhage in a patient wishing to maintain fertility?
Case Report (n=1)
Does oral norgestrel/ethinyl estradiol resolve uterine arteriovenous malformation and associated hemorrhage in a patient wishing to maintain fertility?
Oral norgestrel/ethinyl estradiol may be an effective conservative treatment option for uterine arteriovenous malformation in patients who wish to maintain fertility.
Answers are grounded in this paper and cite their sources.
May support oral contraceptives as fertility-sparing option in uterine AVM; hypothesis-generating and requires prospective validation.
Uterine arteriovenous malformation (AVM) can cause sudden massive hemorrhage. We report a case of uterine AVM following curettage in a patient treated conservatively with an intermediate-dose pill. An 18-year-old gravida 2 para 0 underwent curettage at 12 weeks of gestation and was examined for massive genital hemorrhage that occurred in postoperative month 4. Abundant blood flow in a mass within the uterine lumen was observed on color Doppler ultrasonography, and the patient was diagnosed with AVM. Six days after starting oral norgestrel/ethinyl estradiol, the hemorrhage ceased, and computed tomography on day 37 of administration showed disappearance of the abnormal vasculature. After 12 months, the patient's course remains favorable without relapse. Transarterial embolization for AVM can cause ovarian failure and subsequent placental malpositioning. Administration of oral norgestrel/ethinyl estradiol may be an alternative conservative treatment option for patients who wish to maintain fertility.
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Oride et al. (2014) conducted a case report in Uterine arteriovenous malformation (n=1). oral norgestrel/ethinyl estradiol was evaluated on cessation of hemorrhage and disappearance of abnormal vasculature. Administration of oral norgestrel/ethinyl estradiol led to the cessation of hemorrhage and disappearance of abnormal vasculature in a patient with uterine arteriovenous malformation.
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