Design, Syntheses and Pharmacology of ATP Analogues Selective for Subtypes of P2-Purinoceptors

A series of analogues of adenine nucleotides have been synthesized and tested for Pharmacological potency and resistance to dephosphorylation at a variety of isolated tissue preparations where ATP is active. Structure-activity studies defined four subtypeso f purinoceptors, and enabled the design of specific agonists for P2x and for P2y purinoceptors to be undertaken. L-Adenosine 5′-β, γ-methylenetriphosphonate (L-AMP-PCP) is a specific P2x purinoceptor agonist, and adenosine 5′-β-fluorodiphosphate (ADP-β-F) is a specific P2y agonist.