Key result
2-Azidoadenosine inhibits platelet aggregation more than adenosine, while 2-azido-ADP is ~5x more potent than ADP.
Population
Human platelets
Comparison
Photolysable 2-azido analogues of adenosine… vs Adenosine, AMP, ADP, 2-chloroadenosine, and…
Design
Preclinical
Authors
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These analogues may enable platelet receptor labeling studies; clinical translation in humans remains untested.
Photolysable 2-azido analogues of adenosine, AMP, and ADP are potent modulators of human platelet aggregation and can be used to label their respective receptors.
Cusack et al. (1977) studied this question. Photolysable 2-azido analogues of adenosine, AMP and ADP vs. Adenosine, AMP, and ADP was evaluated on Platelet aggregation and cAMP levels. 2-Azidoadenosine inhibited platelet aggregation more than adenosine, while 2-azido-ADP was about five times more potent than ADP in causing aggregation.
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