May 1, 1982British Journal of PharmacologyOpen Access

Adenosine 5′‐diphosphate Antagonists and Human Platelets: No Evidence That Aggregation and Inhibition of Stimulated Adenylate Cyclase Are Mediated by Different Receptors

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Why the study?

Are ADP-induced aggregation and inhibition of stimulated adenylate cyclase mediated by different receptors in human platelets?

Population

Human platelets

Design

Preclinical

Authors

NCNoel J. CusackUniversity of London SHS.M.O. HouraniUniversity of Surrey

Discussion

Member takes

Implication

Supports shared ADP receptor mediation in platelets; leaves open human in vivo confirmation.

Structured PICO

Are ADP-induced aggregation and inhibition of stimulated adenylate cyclase mediated by different receptors in human platelets?

Population

Human platelets

Intervention

Adenosine 5'-triphosphate and seven adenine nucleotide analogues

Outcome

Correlation between pA2 values for inhibition of ADP-induced aggregation and pA2 values for inhibition of the effect of ADP on stimulated adenylate cyclasesurrogate

The strong correlation between the inhibition of ADP-induced aggregation and adenylate cyclase inhibition suggests both effects are mediated by the same ADP receptor on human platelets.

Cite This Study

Cusack et al. (1982) studied this question.

synapsesocial.com/papers/6a89b870755d28965dfd5248 https://doi.org/10.1111/j.1476-5381.1982.tb09210.x

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