Why the study?
Does ADP-beta-S act as a partial agonist on human platelets compared to ADP?
Does ADP-beta-S act as a partial agonist on human platelets compared to ADP?
ADP-beta-S acts as a partial agonist on human platelets, inducing aggregation and inhibiting adenylate cyclase but with less potency than ADP.
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ADP-beta-S partial agonism at platelet receptors may inform P2Y pharmacology; leaves open human translation from animal data.
Cusack et al. (1981) studied this question.
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