February 1, 1982British Journal of PharmacologyOpen Access

Specific but Noncompetitive Inhibition by 2‐alkylthio Analogues of Adenosine 5′‐monophosphate and Adenosine 5′‐triphosphate of Human Platelet Aggregation Induced by Adenosine 5′‐diphosphate

View Full Paper

Ask AI

Bookmark

Why the study?

Do 2-alkylthio derivatives of AMP and ATP inhibit ADP-induced human platelet aggregation?

Population

Human platelets (in vitro model)

Comparison

2-alkylthio derivatives of AMP, AMPS, and ATP vs Absence of inhibitor

Design

Preclinical

Authors

NCNoel J. CusackUniversity of London SHS.M.O. HouraniUniversity of Surrey

Discussion

Member takes

Implication

These analogues merit preclinical optimization as antiplatelet leads; leaves open translation to clinical antithrombotic use.

Structured PICO

Do 2-alkylthio derivatives of AMP and ATP inhibit ADP-induced human platelet aggregation?

Population

Human platelets (in vitro model)

Intervention

2-alkylthio derivatives of AMP, AMPS, and ATP (100 microM)

Comparator

Absence of inhibitor

Outcome

Inhibition of ADP-induced platelet aggregationsurrogate

2-alkylthio analogues of AMP and ATP act as specific, noncompetitive inhibitors of ADP-induced platelet aggregation in vitro.

Cite This Study

Cusack et al. (1982) studied this question.

synapsesocial.com/papers/6a946f6d5cc4cfd2f72dddfc https://doi.org/10.1111/j.1476-5381.1982.tb08800.x

View Full Paper

Ask AI

Bookmark

Specific but Noncompetitive Inhibition by 2‐alkylthio Analogues of Adenosine 5′‐monophosphate and Adenosine 5′‐triphosphate of Human Platelet Aggregation Induced by Adenosine 5′‐diphosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specific but Noncompetitive Inhibition by 2‐alkylthio Analogues of Adenosine 5′‐monophosphate and Adenosine 5′‐triphosphate of Human Platelet Aggregation Induced by Adenosine 5′‐diphosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider