The RP and SP diastereoisomers of adenosine 5'-O-(1-thiodiphosphate) are the first reported ADP analogues that induce platelet aggregation without inhibiting PGE1-stimulated adenylate cyclase.
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May serve as tools to dissociate aggregation from adenylate cyclase effects; hypothesis-generating and should not change practice.
Cusack et al. (1981) studied this question.
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