Why the study?
Do adenosine derivatives and antihistaminics inhibit ADP- and collagen-induced platelet aggregation?
Do adenosine derivatives and antihistaminics inhibit ADP- and collagen-induced platelet aggregation?
Adenosine derivatives and antihistaminics demonstrate specific inhibitory effects on ADP- and collagen-induced platelet aggregation in vitro.
Preclinical antiplatelet effects do not support clinical use; leaves open targeted drug development in humans.
The inhibitory activity of ade-nosine derivatives on ADP induced platelet aggregation appears to be quite specific. Only one derivative, 5′-adamantoyl adenosine, retained the potency of adenosine. Isoadenosine was 1/100 as active as adenosine. Isoadenosine diphosphate did not induce platelet aggregation at a dose as high as 2.6 × 10- M as compared to ADP which produces extensive aggregation at 4.2 × 10-7 M. All of the 6 antihistaminics tested inhibited ADP induced aggregation, but there was no correlation between antihistaminic and aggregation inhibitory potency. Both classes of compounds also inhibited collagen induced aggregation.
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Herrmann et al. (1966) studied this question.
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