Key result
Non-invasive markers including Haptoglobin, Alpha-2 macroglobulin, and Apolipoprotein-A1 were not significant in predicting hepatic fibrosis on histology (p > 0.05).
Why the study?
Due to the limitations of liver histology for assessing hepatic fibrosis in NAFLD, noninvasive tests have been developed as potential alternatives to liver biopsy.
Do non-invasive markers of fibrosis accurately predict hepatic fibrosis on liver biopsy in patients with NAFLD?
Cross-Sectional (n=25)
No
Do non-invasive markers of fibrosis accurately predict hepatic fibrosis on liver biopsy in patients with NAFLD?
p-value: p=>0.05
In a small cohort of NAFLD patients, non-invasive markers like Haptoglobin, Alpha-2 macroglobulin, and Apolipoprotein-A1 did not significantly predict hepatic fibrosis, though HOMA-IR correlated with inflammation and fibrosis.
Non-invasive markers should not yet guide fibrosis assessment in NAFLD; leaves open larger prospective validation of HOMA-IR associations.
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease & liver transplantation and its incidence is increasing even in Asian countries. The gold standard for assessing hepatic fibrosis is liver histology but due to its limitations, noninvasive tests to assess hepatic fibrosis which can be used as alternative to liver biopsy have been developed. In a cross-sectional study, 25 diagnosed NAFLD patients underwent detailed laboratory investigations including the specific non-invasive markers of fibrosis namely, Haptoglobin, Alpha-2 macroglobulin, Apolipoprotein- A1 levels and Insulin Resistance was calculated by Homeostasis Model Assessment (HOMA), then patients were subjected to liver biopsy. Out of 25 patients, 19(76%) were male and 6(24%) were females. Nine patients (36%) were diabetic and 21 (84%) were dyslipidemiac. Metabolic syndrome was present in 18(72%), body mass index was increased in 22 patients and waist hip ratio was altered in 22 patients (88%). Using SPSS 10, p value was significant (p= 0.04) for correlation between steatosis and waist/hip ratio and HOMA-IR with inflammation and fibrosis (p=0.03) but non-invasive markers were not significant in predicting hepatic fibrosis on histology.
No takes yet. Share an insight, caveat, or question.
Malhotra et al. (2018) conducted a cross-sectional in Nonalcoholic fatty liver disease (n=25). Non-invasive markers of fibrosis (Haptoglobin, Alpha-2 macroglobulin, Apolipoprotein-A1) vs. Liver biopsy was evaluated on Prediction of hepatic fibrosis on histology using non-invasive markers (p=>0.05). Non-invasive markers including Haptoglobin, Alpha-2 macroglobulin, and Apolipoprotein-A1 were not significant in predicting hepatic fibrosis on histology (p > 0.05).