Key result
In vivo pulse waveforms detected at the skin surface by a barometer-based prototype were highly correlated (correlation coefficient: 0.926±0.07) with those obtained from the radial arterial wall by US-rPWI.
Why the study?
Existing tactile pulse sensors only access the superficial tissue layer and have not been validated against medical imaging of the radial artery and its pulsation.
Effect estimate: correlation coefficient: 0.926±0.07
A novel barometer-based pulse-sensing device showed high correlation with high-frequency ultrasound for detecting radial pulse waveforms, supporting its potential for point-of-care pulse assessment.
May inform wrist pulse sensor validation; leaves open clinical utility pending prospective trials.
Wrist-site pulse-sensing devices have drawn increasing attention for daily monitoring of human body conditions in the context of western medicine and modernization of traditional Chinese medicine (TCM) palpation. Existing tactile pulse sensors are deemed to only access the superficial tissue layer as surface detectors but have not been validated against medical imaging of the radial artery and its pulsation. We hereby proposed to employ high-frequency (15.6MHz) and high frame-rate (1000fps) ultrasound radial pulse wave imaging (US-rPWI) to substantiate human radial pulse-taking. We first presented an easy-to-fabricate, cost-effective pulse-sensing prototype based on a commercial off-the-shelf (COTS) barometer. The prototype performance was evaluated using a homemade pressurized vessel-mimicking phantom and 30 differentin vitropulses outputted from a TCM palpation training machine. Phantom experiments evidenced accurate portrayal of dynamic pressure waveforms (mean distortion ratio: 3.38±0.07%, compared with the ground truth).In vivovalidation on human pre- and post- prandial pulses was further performed. US-rPWI revealed significantly diminished pulse amplitudes and gradual waveform deformation from the arterial wall to the skin layer. Nevertheless,in vivopulse waveforms detected at the skin surface by the prototype were highly correlated (correlation coefficient: 0.926±0.07) with those obtained from the radial arterial wall by US-rPWI. Moreover, the changes in post-prandial pulse waveforms detected by both the prototype and US-rPWI were in excellent agreement with those in TCM literature, thus demonstrating the sensitivity of human pulse-taking in quantitative assessment of health conditions at the point of care and providing more clinical evidence for the modernization of TCM sphygmology.
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Tang et al. (2022) studied Human pre- and post-prandial pulses. Barometer-based pulse-taking device vs. High-frequency ultrasound radial pulse wave imaging (US-rPWI) was evaluated on Correlation of in vivo pulse waveforms detected at the skin surface by the prototype with those obtained from the radial arterial wall by US-rPWI (correlation coefficient: 0.926±0.07). In vivo pulse waveforms detected at the skin surface by a barometer-based prototype were highly correlated (correlation coefficient: 0.926±0.07) with those obtained from the radial arterial wall by US-rPWI.
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