Key result
Four pediatric cases of Kawasaki disease presented with coronary artery aneurysms and demonstrated a good response to chemotherapy.
Case Report (n=4)
This case series documents the echocardiographic presentation of coronary artery aneurysms in four pediatric patients with Kawasaki disease and their response to therapy.
No immediate practice change; hypothesis-generating for chemotherapy response in pediatric coronary aneurysms.
Kawasaki disease (KD) is associated with coronary artery lesion, especially in the form of aneurysm and ectasia. The first case is 1-year, 9-month-old female; the second is a 13-month-old male, the third is a 14-month-old female, and the fourth is a 5-year, 6-month-old male who all satisfied the criteria of KD. Echocardiography done for all the series showed dilatation of the left anterior descending coronary artery measuring 2.15 mm with Z score of 2.53 and focal dilatation of left main coronary artery with maximum diameter of 2.9 mm with Z score of 2.44 for the first case, prominent left coronary artery measuring 2.19 mm with Z score of 1.28 with borderline dilatation of the circumflex coronary artery measuring 2 mm with a Z score of 2.13 for the second case, and left coronary dilatation measuring 3.5 mm with Z score of 3.61 and borderline left coronary artery dilatation measuring 3.5 mm with a Z score of 2.24, respectively, for the last two cases. We documented four cases of KD as much as we know, and all the four cases presented with coronary artery aneurism with a good response to chemotherapy.
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Chinawa et al. (2017) conducted a case report in Kawasaki disease (n=4). Chemotherapy was evaluated on Coronary artery aneurysm/dilatation and response to treatment. Four pediatric cases of Kawasaki disease presented with coronary artery aneurysms and demonstrated a good response to chemotherapy.
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