Key result
Bivalirudin provided successful anticoagulation during cardiopulmonary bypass for Total Artificial Heart implantation in a patient with heparin-induced thrombocytopenia, though complicated by bleeding likely from cell saver use.
Case Report (n=1)
No
Bivalirudin is a feasible anticoagulant for cardiopulmonary bypass during Total Artificial Heart implantation in patients with HIT, though caution is needed with cell saver use due to bleeding risks.
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May support bivalirudin in HIT-TAH cases; hypothesis-generating and should not yet change practice.
Federman et al. (2014) conducted a case report in Heparin-induced thrombocytopenia and idiopathic dilated cardiomyopathy requiring Total Artificial Heart (n=1). Bivalirudin was evaluated on Successful anticoagulation during cardiopulmonary bypass. Bivalirudin provided successful anticoagulation during cardiopulmonary bypass for Total Artificial Heart implantation in a patient with heparin-induced thrombocytopenia, though complicated by bleeding likely from cell saver use.
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