Hesperidin, A Citrus Bioflavonoid Attnuates Iron- Induced Biochemical Oxidative Stress in Mouse Liver

Iron is an essential element, which is abundant in the red blood cells and plays a key role during oxidative phosphorylation in the mitochondria of all cells. The excess of iron has been indicated in several diseases as it induces oxidative stress. The present study was undertaken to understand the modulation of iron induce oxidative stress in mice by hesperidin. The mice were administered with 250 mg/kg body weight of hesperidin for five days before feeding with 5000, 10,000 and 20000 ppm FeCl3 for 30 days. The glutathione, glutathione-s-transferase, catalase, superoxide dismutase, lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels were estimated in the liver of iron treated mice after 30 days post-iron treatment. The feeding of different concentrations of iron for 30 days led to an increase in the oxidative stress as indicated by a decline in the glutathione concentration, and glutathione-s-transferase, catalase, and superoxide dismutase activities accompanied by the rise in the lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels.