Key result
New benzofuroindole analogues were designed and synthesized as potent BKCa channel openers showing calcium-independent activation, with potential therapeutic use in neuronal damage.
Newly synthesized benzofuroindole analogues act as potent BKCa channel openers with calcium-independent activation, showing potential therapeutic utility for conditions like stroke and hypertension.
These analogues expand BKCa modulator options for neuronal damage; leaves open translation from animal models to clinical use.
Toward drugs to treat neuronal damage. The design and synthesis of new, potent, large-conductance, calcium-activated potassium-channel (BKCa) openers that show calcium-independent activation in electrophysiological evaluations have been brought about through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa-channel opener (BMS-204352; see scheme). These new channel openers might find therapeutic use in stroke, asthma, hypertension, convulsion, and traumatic brain injury.
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Gormemis et al. (2005) studied Neuronal damage. Benzofuroindole analogues vs. BMS-204352 was evaluated on Calcium-independent activation in electrophysiological evaluations. New benzofuroindole analogues were designed and synthesized as potent BKCa channel openers showing calcium-independent activation, with potential therapeutic use in neuronal damage.
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