Key result
GRIF-1 binds to the Kir2.1 potassium channel and facilitates its trafficking to the cell surface, enhancing Kir2.1-dependent growth in yeast and Rb+ efflux in HEK293 cells.
Population
Yeast expressing mammalian K(+) channel Kir2.1, HEK293 cells, COS cells, and brain lysate
Design
Preclinical
Authors
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Should not alter clinical management of channelopathies; leaves open TRAK2's role in Kir2.1-related cardiac excitability for in vivo study.
GRIF-1 (TRAK2) is identified as a novel trafficking factor that binds to the Kir2.1 potassium channel and facilitates its expression at the cell surface.
Grishin et al. (2006) studied this question. GRIF-1 (TRAK2) was evaluated on Kir2.1 channel trafficking and activity. GRIF-1 binds to the Kir2.1 potassium channel and facilitates its trafficking to the cell surface, enhancing Kir2.1-dependent growth in yeast and Rb+ efflux in HEK293 cells.
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