The role of adiposopathy in the development of obesity-related diseases

Obesity is associated with many related diseases. However, the mechanisms of their occurrence are still not clear. Purpose of the review. To analyze the role of adipozopathy in the mechanism of developing obesity-related diseases. Materials and Methods. The search for published data was made in the MedLine (PubMed) and eLibrary databases. Results. An adipose tissue growth theory suggests that adipose tissue expansion is not due to an increase in absolute number of adipose tissue cells but their growing ability to accumulate lipids and thus influence the metabolic homoeostasis. When the adipose tissue expansion limit is achieved, the lipids migrate and deposit in other organs. Ectopic accumulation of lipids causes lipotoxic effects resulting in metabolic diseases. This review discusses possible mechanisms of adipose tissue expansion disorders and examples of diseases that confirm this theory. Conclusion. A weight loss program adaptation to improve an individual’s metabolic indices instead of general values based on population studies may result in more successful treatment of obesity and metabolic diseases.