Key result
Obesity-related metabolic abnormalities may be driven by impaired adipose tissue function and plasticity rather than just fat accumulation, leading to ectopic fat deposition and lipotoxicity.
Design
Review
Authors
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Adipose dysfunction may inform obesity risk stratification beyond BMI; leaves open targeted interventions pending prospective trials.
Discusses the adipose tissue expandability hypothesis and the role of adipose tissue remodeling and progenitor cells in obesity-related metabolic dysregulation.
Jaswinder K. Sethi (2010) conducted a review in Obesity. Obesity-related metabolic abnormalities may be driven by impaired adipose tissue function and plasticity rather than just fat accumulation, leading to ectopic fat deposition and lipotoxicity.
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