Key result
White adipose tissue expansion capacity shapes metabolic health in obesity via emerging isotopic labeling methods.
Why the study?
The role of adipogenesis in the transition from impaired subcutaneous white adipose tissue expansion to impaired metabolic health remains debated.
This review highlights emerging concepts on white adipose tissue expansion and turnover, and their significance in obesity and metabolic health.
Answers are grounded in this paper and cite their sources.
Leaves open adipogenesis contribution to metabolic impairment in obesity; hypothesis-generating, requiring prospective trials before clinical consideration.
White adipose tissue (WAT) expands under physiological conditions via an increase in adipocyte size (hypertrophy) and/or number (hyperplasia; adipogenesis), and the ability of WAT to expand to accommodate energy demands is a significant determinant of metabolic health status. Obesity is associated with impaired WAT expansion and remodeling, which results in the deposition of lipids to other non-adipose organs, leading to metabolic derangements. Although increased hyperplasia has been implicated as a cornerstone in promoting healthy WAT expansion, recent developments suggest that the role of adipogenesis as a contributing factor in the transition from impaired subcutaneous WAT expansion to impaired metabolic health remains up for debate. This mini-review will summarize recent developments and highlight emerging concepts on the features of WAT expansion and turnover, and the significance in obesity, health, and disease.
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Ursula White (2023) conducted a review in Obesity and metabolic health. White adipose tissue expansion capacity is a significant determinant of metabolic health in obesity, with emerging isotopic labeling methods providing new insights into in vivo lipid and cell kinetics.
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