Key result
Adipocyte progenitors play a key role in obesity-associated white adipose tissue expansion, inflammation, and fibrosis.
Why the study?
The expansion and inflammation of white adipose tissue are causally linked to metabolic and cardiovascular diseases, but the primary event triggering this inflammatory expansion remains unclear.
This review highlights the role of adipocyte progenitors in obesity-associated white adipose tissue expansion, inflammation, and fibrosis, which are linked to metabolic and cardiovascular diseases.
Answers are grounded in this paper and cite their sources.
May inform obesity-related cardiovascular risk mechanisms; leaves open targeted progenitor therapies.
Adipose tissue is an important organ in our body, participating not only in energy metabolism but also immune regulation. It is broadly classified as white (WAT) and brown (BAT) adipose tissues. WAT is highly heterogeneous, composed of adipocytes, various immune, progenitor and stem cells, as well as the stromal vascular populations. The expansion and inflammation of WAT are hallmarks of obesity and play a causal role in the development of metabolic and cardiovascular diseases. The primary event triggering the inflammatory expansion of WAT remains unclear. The present review focuses on the role of adipocyte progenitors (APS), which give rise to specialized adipocytes, in obesity-associated WAT expansion, inflammation and fibrosis.
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Liu et al. (2020) conducted a review in Obesity-associated white adipose tissue expansion, inflammation, and fibrosis. Adipocyte progenitors (APS) was evaluated. Adipocyte progenitors play a key role in obesity-associated white adipose tissue expansion, inflammation, and fibrosis.
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