Key result
Vascular endothelial cells from murine and human adipose tissue are pluripotent and can give rise to a population of brown and white adipocytes.
Population
Murine endothelial cells (VE-Cadherin-Cre transgenic mouse model) and human adipose tissue capillary sprouts
Design
Preclinical
Authors
Loading...
Animal models identify adipocyte progenitors in obesity; leaves open translation to human therapies or mechanisms.
Vascular endothelium can give rise to a population of brown and white fat cells, providing a mechanistic link between angiogenesis and adipogenesis.
Khanh‐Van Tran (2012) studied Obesity. Lineage tracing and PPARγ activation was evaluated on Endothelial origin of adipocytes. Vascular endothelial cells from murine and human adipose tissue are pluripotent and can give rise to a population of brown and white adipocytes.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: