Key result
White-to-brown adipocyte transdifferentiation is associated with obesity resistance, while visceral adipocyte death and macrophage infiltration contribute to insulin resistance and Type 2 diabetes.
Population
Mammals including humans (focus on white and brown adipocytes in visceral and subcutaneous depots)
Design
Review
Authors
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Highlights potential adipocyte plasticity targets for obesity and diabetes; leaves open clinical translation pending human interventional data.
Understanding the plasticity and transdifferentiation between white and brown adipocytes offers potential therapeutic targets for obesity and type 2 diabetes.
Saverio Cinti (2011) conducted a review in Obesity and Type 2 diabetes. White-to-brown adipocyte transdifferentiation is associated with obesity resistance, while visceral adipocyte death and macrophage infiltration contribute to insulin resistance and Type 2 diabetes.
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