Key result
Dysfunctional adipocytes, ectopic fat accumulation, and adipose tissue resistance to insulin's antilipolytic effect play a central role in the development of impaired glucose metabolism.
Design
Review
Authors
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May guide adipose-targeted metabolic research; leaves open interventional trials before clinical application.
Adipose tissue composition and function, rather than just total fat mass, are critical determinants in the development of metabolic diseases.
Gaggini et al. (2017) conducted a review in Metabolic diseases. Adipose tissue metabolism and composition was evaluated. Dysfunctional adipocytes, ectopic fat accumulation, and adipose tissue resistance to insulin's antilipolytic effect play a central role in the development of impaired glucose metabolism.
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