Key result
Visceral and ectopic fat increase the risk of developing insulin resistance, type 2 diabetes, and cardiovascular diseases, whereas brown adipose tissue may positively modulate cardiometabolic risk.
Design
Review
Authors
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Supports fat depot-specific risk assessment in practice; leaves open brown adipose tissue activation as a therapeutic target pending trials.
This review highlights the differential roles of adipose tissue depots, emphasizing that visceral and ectopic fat increase cardiometabolic risk while brown adipose tissue activation may offer therapeutic benefits.
Gaggini et al. (2015) conducted a review in cardiometabolic diseases. Visceral and ectopic fat was evaluated. Visceral and ectopic fat increase the risk of developing insulin resistance, type 2 diabetes, and cardiovascular diseases, whereas brown adipose tissue may positively modulate cardiometabolic risk.
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